Although in guy, cholestyramine resin creates an increase in hepatic synthesis of cholesterol, plasma cholesterol levels drop.
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In scientific studies conducted in rats wherein cholestyramine resin was used as a Software to research the role of various intestinal components, such as Body fat, bile salts and microbial flora, in the development of intestinal tumors induced by strong carcinogens, the incidence of such tumors was observed to get bigger in cholestyramine resin-treated rats than in control rats.
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The commonest adverse response is constipation. When used to be a cholesterol-lowering agent, predisposing variables for most issues of constipation are significant dose and increased age (in excess of 60 a long time outdated).
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Cholestyramine resin may possibly develop or worsen pre-current constipation. The dosage should be increased steadily in individuals to minimize the risk of creating fecal impaction. In individuals with pre-present constipation, the starting dose should be one packet or 1 scoop once daily for five to 7 days, expanding to two times day-to-day with monitoring of constipation and of serum lipoproteins, at the least 2 times, four to 6 months aside. Increased fluid consumption and fiber intake should be encouraged to alleviate constipation and a stool softener might at times be indicated.